Poster Session 1
Daniel J. Martingano, DO, MBA, PhD
Clerkship Director, IRB Chair, Associate Program Director / Division Chair
St. John's Episcopal Hospital-South Shore and William Carey University College of Osteopathic Medicine
Far Rockaway, New York, United States
Marwah Al-Dulaimi, MD (she/her/hers)
OB/GYN Resident
St. John's Episcopal Hospital-South Shore
Far Rockaway, NY, United States
Sandra Kumwong, MS
Medical Student
Touro College of Osteopathic Medicine-Harlem Campus
New York, New York, United States
Andrea Ouyang, MSc
Medical Student
William Carey University
Hattiesburg, Mississippi, United States
Lauren Cue, MD, BA (she/her/hers)
OB/GYN Resident
Rutgers University and the Jersey City Medical Center
Jersey City, New Jersey, United States
Ashley Nguyen, MD
OB/GYN Resident
St. John's Episcopal Hospital-South Shore
Far Rockaway, New York, United States
Alexander Ulfers, DO
Medical Director, Maternal Infant Care Center; Maj, USAF, MC
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Mark Rebolos, MD
Director of Patient Safety, Labor & Delivery
St. John's Episcopal Hospital-South Shore
Far Rockaway, New York, United States
Kristin Cohen, CNM, DNP
Women's Health Care Practitioner
RWJBarnabas Health - Trinitas Regional Medical Center
Elizabeth, New Jersey, United States
Shailini Singh, MD
Director of Metabolic Syndrome
AtlantiCare Regional Medical Center
Pamona, New Jersey, United States
Amanda F. Francis Oladipo, MD, MSCR (she/her/hers)
Director of Research
Hackensack University Medical Center
Hackensack, New Jersey, United States
Francis X. Martingano, MD
Assistant Professor, Senior Minimally Invasive Surgeon
NYU Grossman School of Medicine - NYU Brooklyn
New York, New York, United States
Donald Morrish, MD
Chief Executive Officer
St. John's Episcopal Hospital-South Shore
Far Rockaway, New York, United States
Iffath A. Hoskins, MD
Former ACOG President, Director of Labor & Delivery, Chief Safety Officer
Albert Einstein College of Medicine - Montefiore Medical Center
New York, New York, United States
Long Covid (LC) is a collective term referring to the persistence of symptoms and complications related to those acquiring an acute SARS-CoV-2 infection. This study sought to evaluate the effects of medications often employed empirically in the management of LC for pregnant patients in the 3rd trimester and postpartum periods.
Study Design:
We conducted a multi-center, prospective observational study from 7/2022 to 7/2024 comparing all pregnant women diagnosed with SARS-CoV-2 infection (CoV-2) in the 3rd trimester through 6 weeks postpartum. Patients with preexisting respiratory or neurological disorders or preterm delivery < 37 weeks-gestation, were excluded. Medications including enoxaparin, aspirin, inhaled corticosteroids with or without a long-acting beta blocker (CBB), theophylline, antidiabetic medications, and 1st generation antihistamines were included as covariates. The primary outcomes included the development of LC and improvement or worsening following treatment. Primary outcomes were determined by patient-reported symptoms confirmed by physician assessment in the immediate, 1-week (1P), and 6-week postpartum (6P) periods, as discrete events.
Results:
The study included 369 patients diagnosed with LC. Patients who received enoxaparin were less likely to report LC at the 1P and 6P visits (39.7% v. 47.9%, p = 0.004). Patients receiving aspirin antepartum were also less likely to report LC at the same intervals (25.8% v. 51.2%, p = 0.001). Patients with LC were more likely to report improvement when taking aspirin at doses of at least 325mg (31.8% v. 11.9%, p = 0.022). In stratified analysis, patients with diabetes in pregnancy and received metformin were less likely to report LC at the 1P and 6P visits (22.7% v. 48.2%, p = 0.004). Patients with LC who received semaglutide were more likely to report worsening status at the 6P visit (45.2% v. 54.8%, p=0.045).
Conclusion:
These findings suggest that treatments targeting the circulatory system may prove more useful for LC in the 3rd trimester and postpartum period, with a possible extended benefit when using metformin in diabetic patients.
