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Poster Session 2

(433) Early pregnancy levels of acute phase reactants in maternal serum and pregnancy outcomes

Thursday, January 30, 2025
4:00 PM – 6:00 PM  

    Submitting Author and Presenting Author(s)

  • Ayal Haimov, BSc (he/him/his)

    Ben Gurion University of the Negev
    Ramat Gan, HaMerkaz, Israel

    • Coauthor(s)

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology, Soroka University Medical Center
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

Objective: Inflammation and infection within the fetoplacental unit have been suggested as a mechanism involved in pregnancy complications. The goal of this study was to investigate the association between early pregnancy maternal serum levels of the following acute phase reactants (ARPs): CRP (C- reactive protein), albumin, triglyceride, HDL and selected pregnancy outcomes.  

Study Design: A prospective cohort study was conducted, including pregnant women with a singleton pregnancy, recruited between 11-13 gestational weeks. The independents variables were serum levels of the following ARPs: CRP, Albumin, Triglyceride, and HDL. The incidence of the following pregnancy outcomes was compared between women with high and low levels of the measures APRs: abortion, hypertensive disorders, gestational diabetes mellitus, gestational length, preterm birth (PTB), birth weight, low birthweight, macrosomia, cesarean delivery and low 5 minutes Apgar score.

Results:

The study included 201 women. No association was found between the ARPs and pregnancy outcomes (Table 2), for instance, the incidence of PTB were 5.8% (n=8) versus 5.5% (n=3), among women with high and low HDL, respectively (p=0.917), and 5.3% (n=6) versus 6.6% (n=5) among women with high and low Albumin, respectively (p=0.704). Birth weight was 3220.75 ± 403 versus 3317.51 ± 467 grams among women with low and high CRP, respectively (p=0.160), and 3296.39 ± 433.26 versus 2676.05 ± 464.76 grams among women with high and low Albumin, respectively (p=0.758). These findings were supported by multivariable logistic and linear models, which adjusted for maternal BMI and maternal age.

Conclusion: Based on the current study, early pregnancy levels of ARPs are not associated with an increased risk for adverse pregnancy outcomes.