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Poster Session 2

(432) Early pregnancy levels of cholesterol in maternal serum and pregnancy outcomes

Thursday, January 30, 2025
4:00 PM – 6:00 PM  

    Submitting Author and Presenting Author(s)

  • Ayal Haimov, BSc (he/him/his)

    Ben Gurion University of the Negev
    Ramat Gan, HaMerkaz, Israel

    • Coauthor(s)

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology, Soroka University Medical Center
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

Objective: Elevated maternal serum lipid concentrations during late pregnancy are associated with pregnancy complications. The goal of this study was to investigate the association between early pregnancy maternal serum levels of cholesterol and selected pregnancy outcomes.  

Study Design:

A prospective cohort study was conducted, including pregnant women with a singleton pregnancy, recruited between 11-13 gestational weeks. The independent variable was maternal serum level of cholesterol (high cholesterol was defined as >200 mg/dL). The incidence of the following pregnancy outcomes was compared between women with high and low cholesterol: abortion, gestational hypertension, gestational diabetes mellitus, gestational length, preterm birth, birth weight, low birthweight, macrosomia, cesarean delivery and low 5 minutes Apgar score.

Results: The study included 201 women. The incidence of high cholesterol was 35% (n=70). Mean birthweight was higher among women with high cholesterol (Table 2, 3392.71 ± 426 versus 3220.78 ± 448 grams, p-value = 0.01). Similarly, women with high cholesterol were more likely to deliver a macrosomic newborn (10.1% versus 3.2%, p-value = 0.057). Multivariable linear model, adjusted for gender and maternal diseases, found that an increase in one unit of cholesterol was significantly related with an increase of 2.85 grams in birthweight (95% CI= 0.98 - 4.73, p-value = 0.003). Multivariable logistic model which adjusted for gender and maternal BMI, found that every unit increase of cholesterol was significantly related with an increased risk for macrosomia (OR=1.025, 95% CI= 1.003 – 1.047, p-value = 0.025). No association was found between cholesterol and others pregnancy outcomes.

Conclusion: Higher birthweight and a risk for macrosomia were found among women with high early pregnancy cholesterol levels, even after controlling for maternal BMI. Lowering maternal cholesterol levels may aid in prevention of pregnancy complications associated with high birthweight.