(1203) The effect of one-abnormal glucose-value of the 100-gram oral-glucose tolerance-test according to Carpenter-and-Coustan on obstetrical-outcomes

To examine the effect of one abnormal glucose value only according to C&C criteria in 100 g OGTT on pregnancy outcomes.

Study Design: A population-based retrospective cohort study was conducted involving women who delivered at Tzafon Medical Center in Israel between March 2012 and December 2022. The women were categorized into three groups: (1) those without GDM (either normal GCT or OGTT; N=18,422), (2) those with one abnormal OGTT value according to C&C criteria (fasting glucose 95-104, one hour 180-189, two hours 155-164, and three hours 140-144 mg/dL; N=371), and (3) those with GDM, defined as at least two abnormal OGTT values according to C&C (N=431). Only the last group was officially diagnosed with GDM. The primary outcome measured was the rate of large for gestational age (LGA) neonates.

Results:

Univariable and multivariable analyses are detailed in Tables 1 and 2. After adjusting for background characteristics, having one abnormal glucose value significantly increased the risk, compared to the control group, and similar to the values in the two pathologic values group, for the following outcomes: large for gestational age (LGA) neonates (adjusted OR 1.5, 95% CI [1.2-2.0]), macrosomia (2.0, 95% CI [1.3-2.8]), cesarean delivery (1.5, 95% CI [1.2-1.9]), and hypertensive disease of pregnancy (2.0, 95% CI [1.3-3.3]).

Univariable and multivariable analyses are detailed in Tables 1 and 2. After adjusting for background characteristics, having one abnormal glucose value significantly increased the risk, compared to the control group, and similar to the values in the two pathologic values group, for the following outcomes: large for gestational age (LGA) neonates (adjusted OR 1.5, 95% CI [1.2-2.0]), macrosomia (2.0, 95% CI [1.3-2.8]), cesarean delivery (1.5, 95% CI [1.2-1.9]), and hypertensive disease of pregnancy (2.0, 95% CI [1.3-3.3]).

 

Conclusion:

Women with one abnormal OGTT value, according to the C&C criteria, had worse outcomes compared to normoglycemic women, and similar to those with GDM. Therefore, these women should be considered as having GDM.