(1116) Does maternal age at first pregnancy affect long-term endocrine morbidity of the mother?

Friday, January 31, 2025

4:00 PM – 6:00 PM

Submitting Author and Presenting Author(s)

Moran Shahar, MD

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Beer Sheva, HaDarom, Israel

Coauthor(s)

Eyal Sheiner, MD, PhD

Head of department of Obstetrics and Gynecology, Soroka University Medical Center
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Beer Sheva, HaDarom, Israel
RS

Ruslan Sergienko, MHA

Data Science, Statistical Programming & Analysis, Advanced Data Management
Ben-Gurion University of the Negev
Beer Sheva, HaDarom, Israel
NS

Naama Steiner, MD

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Beer Sheva, HaDarom, Israel
Tamar Wainstock, PhD (she/her/hers)

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Beer Sheva, HaDarom, Israel
Gil Gutvirtz, MD

Soroka University Medical Center
Metar, HaDarom, Israel
RK

Roy Kessous, MD, PhD

Soroka
Beer-Sheva, HaDarom, Israel

Objective: Pregnancies of women of advanced maternal age are associated with various pregnancy and perinatal complications for the mother and the offspring. However, the long-term outcomes of the mothers were scarcely investigated. Our aim was to investigate the association between maternal age at first pregnancy and long-term endocrine morbidity of the mother

Study Design:

In a population-based cohort study, long-term endocrine morbidity of mothers who delivered between 1991-2021 in a regional tertiary medical center was analyzed. Mothers were stratified by 4 age groups (< 30,30-35,35-40, >40). Endocrine morbidity was assessed according to a predefined set of ICD-9 codes and extracted from endocrine-related hospitalization files of the mothers. A Kaplan-Meier survival curve was used to assess cumulative incidence of endocrine morbidity and a Cox proportional hazards model was constructed to control for confounders, comparing the groups of maternal age over 30 to a reference group of women under 30 in their first pregnancy

Results:

During the study period 73258 women were included, of which 67365 (92.0%) women had their first delivery prior to 30 years of age, 4571 (6.2%) were between the ages 30-35, 1069 (1.5%) between the ages 35-40 and 253 (0.3%) were older than 40 years. The total endocrine-related hospitalization rate increased as maternal age increased among the 4 study groups (15.1%, 15.2%, 17.8% and 18.6%, respectively, p=0.004). Likewise, the cumulative incidence of endocrine morbidity over time was higher for women as they were older in their first pregnancy (Figure). The Cox regression model, controlling for fertility treatments and ethnicity, found a ‘dose dependent’ effect as maternal age in the first pregnancy was an independent risk factor for long-term endocrine morbidity of the mother as compared with the reference group of women under 30 years old (Table)

Conclusion:

As women delay their first pregnancy to an older age, they have higher long-term endocrine morbidity later in life. The risk tends to increase in a dose-dependent manner for women over the age of 30 and is highest for women over 40