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CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award

Poster Session 4

(1023) Ureaplasma Colonization in Preterm Premature Rupture of Membranes: Implications for Latency Period and Neonatal Outcomes

Friday, January 31, 2025
4:00 PM - 6:00 PM  
Objective: Ascending microbial invasion is thought to be responsible for many cases of preterm premature rupture of membranes (PPROM). Ureaplasma colonization has been observed in up to 65% of cases and may result in poorer neonatal outcomes. We aimed to assess the prevalence of vaginal colonization with Ureaplasma species in pregnancies complicated by PPROM and determine its correlation with the latency period and pregnancy outcomes.

Study Design: Demographics, pregnancy complications, treatment regimens, and outcomes were analyzed from 165 patients with PPROM and vaginal Ureaplasma testing from 2017-2024 at a tertiary care center. Chi-square, t-test, Wilcoxon rank sum tests, and logistic regression were used to assess Ureaplasma colonization effects.

Results:

Ureaplasma was detected in 57.6% of PPROM patients. Baseline characteristics with significant variations between groups were adjusted for, including advanced maternal age, in vitro fertilization, history of cesarean section, cerclage, and mycoplasma positivity. There was no significant difference in latency periods between Ureaplasma-positive and negative groups (6 [2-12] vs. 5 [2-16] days, p = 0.9).

 

After adjusting for significant differences in characteristics, Ureaplasma colonization was associated with reduced odds of intubation (aOR 0.32, 95% CI 0.15–0.71) and surfactant use (aOR 0.34, 95% CI 0.14–0.79), but did not significantly affect the composite neonatal morbidity (aOR 0.82, 95% CI 0.32–2.10; Table 1). Incidence of preterm birth at < 34 weeks and < 28 weeks (Table 1) and maternal outcomes (Table 2) did not differ between groups after adjusting for characteristics differences.

Conclusion: Ureaplasma colonization was common in PPROM patients, however its presence did not significantly affect the latency period. It was associated with specific neonatal outcomes, such as a decreased requirement for neonatal respiratory support. This association suggests the need for further research into the effects of Ureaplasma in pregnancy and the interaction with microbial therapy.