(737) Risk Factors for Preeclampsia Following Early Onset Fetal Growth Restriction

The study included all consecutive individuals admitted to the antepartum unit of a tertiary university affiliated medical center between 2011-2024 for the diagnosis of early onset FGR. Maternal and pregnancy characteristics were recorded, including: maternal age, BMI, smoking, parity, gestational age (GA) at diagnosis, chronic hypertension, maternal cardiac disease, pre- or gestational diabetes, thrombophilia, chronic renal disease, history of major pregnancy complications, mode of conception, number of fetuses, premature contractions, ultrasound (US) measured abdominal circumference (AC), US measured estimated fetal weight (EFW), umbilical artery doppler PI (UAPI) and middle cerebral artery doppler PI (MCAPI).
AC and EFW were classified as < 5% and < %3 respectively based on local population growth charts. UAPI and MCAPI percentiles calculated per specific gestational age.  
We investigated the association of these variables with development of PE using univariate and multivariable logistic regression.

Results: During the study period 774 pregnant individuals were admitted for early-onset FGR, while 79 of them (10.2%) subsequently developed PE. Table 1 presents maternal and pregnancy characteristics according to the development of PE. Using multivariate analysis (Table 2) GA 24-28 weeks at diagnosis (OR 2.54, CI 1.20-5.36, p=0.01), AC below the 5^th percentile (OR 2.31, CI 1.10-4.86, P=0.02), and UAPI above the 95^th percentile (OR 3.35, CI 1.55-7.20, P< 0.01) were significantly associated with the subsequent development of PE.

Conclusion:

Early GA at diagnosis of FGR, AC below the 5^th percentile and UAPI >95^th percentile are significantly associated with the development of PE in pregnancies complicated by early-onset FGR.