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CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award

Poster Session 1

(206) Association between Maternal Age at First Delivery and Long-term Risk for Cardiac Morbidity

Thursday, January 30, 2025
10:30 AM - 12:30 PM  

    Submitting Author and Presenting Author(s)

  • HB

    Hagar Brami, MD

    Soroka
    Beer-Sheva, HaDarom, Israel

    • Coauthor(s)

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology, Soroka University Medical Center
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • RS

    Ruslan Sergienko, MHA

    Data Science, Statistical Programming & Analysis, Advanced Data Management
    Ben-Gurion University of the Negev
    Beer Sheva, HaDarom, Israel

  • RK

    Roy Kessous, MD, PhD

    Soroka
    Beer-Sheva, HaDarom, Israel

Objective: While the global trend of advanced maternal age at first delivery is on the rise, the potential long-term risk for the mothers is yet to be fully elucidated. In our study, we have sought to examine the association between advanced maternal age at first delivery and maternal cardiac morbidity.

Study Design:

A population-based cohort analysis was conducted including all primigravida at a tertiary hospital occurring between 1991 to 2021 divided by four groups of ages (less than 30 years, between 30-35, 35-40 and older than 40 years). Data were collected from medical records according to pre-defined ICD-9 codes. Cardiac outcomes were compared and analyzed. Women with prior cardiac disease were excluded. A Kaplan-Meier survival curve was used to assess cumulative cardiac morbidity. A Cox proportional hazards model was used to control for confounders.

Results:

Out of the 74,543 primigravida included in the study, 1187 women had their first delivery when they were at the ages of 35-40 and 315 were older than 40 years. A linear correlation was found with regard to maternal age at first delivery and cardioac morbidity, showing increasing cumulative incidence of cardiac morbidity with the highest risk for women that delivered first over the age of 40 (Kaplan-Meier log-rank p< 0.001; Figure). This correlation was significantly found in the univariable analysis for overall cardiovascular disease (16.5% vs. 10.3%) and moreover, for specific related diagnoses such as hypertension (10.6% vs. 3.3%) and ischemic heart disease (1.1% vs. 0.2%) (p< 0.001 for all, Table).  A Cox proportional hazards model confirmed that maternal age at first pregnancy is an independent risk factor for cardiovascular morbidity of the mother, and that the risk is higher as maternal age advanced at the first pregnancy (Table).  regarding mothers age reaching a peak in women that give birth for the first time after the age of forty (adjusted HR = 1.96, 95% CI 1.45–2.63, p< 0.001; Table). 

Conclusion:

Maternal age at first delivery in an independent risk factor for cardiac morbidity later in life.