(298) FGR Resolution Trends by Gestational Age at Diagnosis

Thursday, January 30, 2025

10:30 AM – 12:30 PM

Submitting Author and Presenting Author(s)

Mona M. Makhamreh, MD (she/her/hers)

Maternal Fetal Medicine/Medical Genetics and Genomics Fellow
Baylor College of Medicine
Houston, Texas, United States

Coauthor(s)

SW

Sascha Wodoslawsky, BA

Icahn School of Medicine at Mount Sinai
New York, New York, United States
MS

Madeline V. Smith, MPH

Sidney Kimmel Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States
EF

Emily Ferguson, BA

Sidney Kimmel Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States
SM

Samantha Mauser

Sidney Kimmel Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States
LQ

Lucy Qi, BS

Sidney Kimmel Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Rodney A. McLaren, Jr., Jr., MD

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Huda B. Al-Kouatly, MD

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States

Objective: There is little data on the incidence of resolution for fetal growth restriction (FGR) diagnosis. Thus, the objective was to determine the incidence of FGR resolution in women diagnosed with FGR, stratified by the gestational age (GA) at diagnosis.

Study Design: This was a retrospective cohort study at a single institution that included all singleton, non-anomalous pregnancies diagnosed with FGR (defined as estimated fetal weight (EFW) < 10th percentile or abdominal circumference (AC) < 10th percentile) and followed with subsequent ultrasounds. Data were stratified by the GA at FGR diagnosis. Cases were classified as resolved if follow-up ultrasounds demonstrated EFW and AC both at, or above the 10th %. Cases were categorized as persistent if follow-up ultrasounds continued to show FGR without resolution before birth. Data was presented as percentages.

Results: Of the 4900 records reviewed, 666 had FGR. Of these, 637 (95.6%) had follow-up ultrasounds. Among these, 178 (27.9%) resolved before birth. Figure 1 demonstrates the trends of FGR resolution by GA at diagnosis. Table 1 details the course of FGR by GA. The resolution rates varied by gestational age at diagnosis. For cases diagnosed before 20 weeks’ GA, the resolution rate was 53.6%, while cases diagnosed with FGR at 36 weeks GA onwards, the resolution rate was 7.4%. Of 178 FGR cases that resolved, only 2 (1.1%) had elevated UA dopplers that later resolved with FGR resolution.

Conclusion: The incidence of FGR resolution varied with the timing of diagnosis. Early diagnosis was linked to higher resolution rates, while later diagnoses were associated with lower resolution rates. These findings offer valuable insights for counseling patients about FGR and emphasize the importance of follow-up ultrasounds in monitoring fetal growth progression.