Poster Session 2
Noa Leybovitz Haleluya, MD (she/her/hers)
OB/Gyn resident
Soroka Medical Center
Meitar, HaDarom, Israel
Tamar Wainstock, PhD (she/her/hers)
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Beer Sheva, HaDarom, Israel
.jpeg.jpg "Eyal Sheiner, MD, PhD photo")
Eyal Sheiner, MD, PhD
Head of department of Obstetrics and Gynecology, Soroka University Medical Center
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Beer Sheva, HaDarom, Israel
Group B Streptococcus (GBS) colonize the gastrointestinal and the genital tract. Vertical transmission primarily occurs following rupture of membranes or during passage through the birth canal. Early-onset neonatal GBS infection manifests as sepsis, pneumonia, or meningitis, while late-onset GBS disease most often presents as bacteremia. Both are associated with short-term morbidity and mortality. However, the long-term effects are not well established. We aimed to study the association between GBS colonization near and long-term childhood respiratory morbidity of offspring.
Study Design:
A retrospective population based cohort analysis was performed, in which respiratory pediatric morbidity was compared between offspring to mothers with positive GBS and offspring to mothers with negative or unknown GBS status. The analysis included all singletons born between the years 2002-2021 at a tertiary medical center. Infants with congenital malformations, multiple gestations and cesarean deliveries were excluded from the analysis. Data for the diagnosis of respiratory morbidity was extracted from community-based clinics and hospitalization records. A Kaplan-Meier survival curve was constructed to compare the long- term cumulative respiratory morbidity, and a Cox proportional hazards model was used to adjust for confounders
Results:
The study population included 146103 singletons. Positive GBS carrier state was recorded in 2225 (1.5%) patients. The cumulative incidence of long-term respiratory morbidity was comparable between both groups (Figure, Log-rank p=0.540). Selected respiratory morbidities groups are presented in the Table. Using a Cox proportional hazard model, no significant association was noted between GBS colonizationand the risk for long-term pediatric respiratory morbidity, while adjusting for gestational age, maternal age, ethnicity, maternal hypertension and diabetes (Adjusted HR= 1.00, 95%CI 0.93-1.08, p</em>=0.920).
Conclusion:
: GBS colonization in maternal genital tract is not independently associated with a risk for long-term pediatric respiratory morbidity of the offspring
