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Poster Session 3

(765) Maternal history of recurrent pregnancy loss and the risk for offspring inflammatory bowel disease

Friday, January 31, 2025
10:30 AM – 12:30 PM  

    Submitting Author and Presenting Author(s)

  • Gil Gutvirtz, MD

    Soroka University Medical Center
    Metar, HaDarom, Israel

    • Coauthor(s)

  • Gali Pariente, MD

    Acting director of Fetal Maternal Unit B Division of Obstetrics and Gynecology
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology, Soroka University Medical Center
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

Objective: Women with a history of recurrent pregnancy loss (RPL) may harbor a genetic disposition for inflammatory responses causing pregnancy losses. As altered immune response has been implicated in the pathogenesis of inflammatory bowel disease (IBD), we sought to investigate whether offspring of women with RPL are at an increased risk to develop IBD.

Study Design: A population-based cohort study of singleton deliveries was conducted to evaluate the risk for IBD in children (up to the age of 18 years) born to mothers with and without a history of RPL. Data for the diagnosis of IBD of the offspring were extracted from community-based clinics and hospitalization records. Kaplan-Meier survival curve was used to compare the cumulative incidence of IBD between the study groups. A cox proportional hazards model was used to control for confounders.

Results: During the study period (1991-2021), 356,356 singleton deliveries were included in the study, of them, 14,235 (4%) deliveries were in women with a history of RPL. Comparable rates of IBD were documented in children born to mothers with and without a history of RPL (0.1% vs. 0.1%, p=0.104, Figure). The Kaplan-Meier survival curve demonstrated a comparable incidence of IBD in offspring of both groups (Log Rank, p=0.919, Figure). Likewise, using a Cox proportional hazards model, adjusted for maternal age and gestational age at birth, maternal history of RPL was not associated with IBD of the offspring (adjusted hazard ratio (HR)=1.11, 95%CI 0.60-2.05, p=0.731).

Conclusion:

Maternal history of recurrent pregnancy loss is not a risk factor for IBD in the offspring.