Skip to main content
SMFM 2025 Pregnancy Meeting Main banner
Final Program


Program Book
Icon Legend
Presentation Icons
Additional registration fee required
Additional registration fee required
CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Recording
Recording
Poster Icons
Additional registration fee required
Additional registration fee required
Faculty have requested this content not be shared on social media
Faculty have requested this content not be shared on social media
CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Back

Poster Session 3

(740) The association between maternal preeclampsia and the risk for offspring endocrine morbidity– sibling matched analysis

Friday, January 31, 2025
10:30 AM – 12:30 PM  

    Submitting Author and Presenting Author(s)

  • Dor Marciano, MBA, MD, MPH, N/A (he/him/his)

    Soroka university medical center
    Soroka, HaDarom, Israel

    • Coauthor(s)

  • Eyal Sheiner, MD, PhD

    Head of department of Obstetrics and Gynecology, Soroka University Medical Center
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Beer Sheva, HaDarom, Israel

Objective: Emerging research suggests maternal preeclampsia may be linked to long-term endocrine morbidities in offspring, but these studies may be biased due to uncontrolled confounding variables. This sibling-matched study investigates the association between maternal preeclampsia during pregnancy and long-term endocrine hospitalizations in offspring, rigorously controlling for potential confounders.

Study Design: A retrospective population-based cohort study was conducted with parous women diagnosed with preeclampsia in one pregnancy. A sibling-matched analysis compared siblings where one was prenatally exposed to maternal preeclampsia, and the other was not. The incidence of hospitalization for endocrine morbidities, including diabetes mellitus, thyroid disorders, and obesity, was compared between siblings, as well as the time to first hospitalization. Multivariable generalized estimation equation (GEE) analysis adjusted for confounding variables.

Results: Among 8544 siblings, with half born after a preeclamptic pregnancy, the Kaplan-Meier survival curve showed no higher cumulative endocrine-related hospitalization rates in the preeclampsia group (log-rank P = 0.363). The crude rates of total endocrine hospitalizations were comparable between the preeclampsia and non-preeclampsia groups (0.6% vs. 0.5%; OR=0.994; 95% CI 0.992-0.997 P=1.0). After adjusting for confounders such as maternal age, gestational age, and induction of labor, the adjusted hazard ratio from the GEE model was not significant (adjusted HR = 1.112; 95% CI 0.598-2.068 P =0.737).

Conclusion: This sibling-controlled cohort study found no significant association between maternal preeclampsia and long-term endocrine-related hospitalization in offspring after adjusting for potential confounders. These findings suggest that prior associations may have been influenced by unmeasured confounding variables. Further research is needed to validate these results and continue exploring the long-term endocrine implications of maternal preeclampsia.