(732) Twin Pregnancy is a Significant Risk Factor for Delivery within 24 hours in P-PROM

To assess the likelihood of delivery within 24 hours after preterm premature rupture of membranes (P-PROM) in twin pregnancies in comparison to singleton pregnancies.

Study Design:

We conducted a retrospective cohort study in a tertiary university-affiliated medical center with approximately 12,500 deliveries annually (2012-2023). Data collected encompassed demographic and obstetrics characteristics including maternal age, gestational age at delivery, body mass index, parity, mode of delivery, and delivery outcomes. A comparison was made between twin (study group) and singleton (control group) pregnancies with P-PROM (gestational age 24+0-36+6). Statistical analyses, including Cox regression and multivariate logistic regression, were performed to evaluate the impact of twin pregnancies on the likelihood of delivery within 24 hours.

Results:

1) During the study period, 145,883 women delivered in our center. Of them, 1,498 [1%] women were admitted with P-PROM, of whom 297 (19.9%) with twin pregnancies.

2) The characteristics of the two groups differ regarding gestational age at delivery, parity, previous cesarean deliveries, and mode of conception [Table 1].

3) In the study group, 234 women (78.8%) delivered within 24 hours, while 697 women (58.3%) in singleton pregnancies (p-value < 0.001).

4) Using a Cox regression and multivariate logistic regression, twin pregnancy was identified as a significant factor for delivery within 24 hours: HR 2.3 (95%CI 1.9-2.7, p< 0.001) [Table 2].

Conclusion:

Twin pregnancy was found to be the most significant risk factor for delivery within 24 hours in women with P-PROM.