(936) The Impact of Inter-Pregnancy-Interval After Delivery of SGA Fetus on Recurrence Rate - multicenter study

Objective: To evaluate the association between IPI after delivering an SGA infant and the recurrence of this condition in the subsequent pregnancy. This study aims to identify high-risk populations for recurrence and provide counseling on the recommended waiting period before the next pregnancy.

Study Design:

Methods: A multi-center retrospective cohort study. The study population included all women who delivered a live SGA infant between 24-42 weeks of gestation and subsequently conceived and delivered in all university-affiliated obstetrical centers in a single geographic area between 2003 and 2021. The study population was divided into several IPI groups, with an IPI of 18 to 23 months serving as the reference group. The primary outcome measured was the recurrence rate of SGA in the subsequent pregnancy.

Results:

Results: During the study period, 12,689 women who delivered an SGA infant and subsequently delivered again were identified. The control group (IPI between 18-23 months) included 1,765 women. The overall recurrence rate of SGA in the study population was 19.3%. Univariate analysis showed that an IPI of less than 3 months and an IPI between 6 to 11 months were associated with higher rates of SGA recurrence (24.6% vs. 17.5%, p< 0.01 and 20% vs. 17.5%, p=0.03, respectively). However, multivariate analysis controlling for confounders such as maternal age, gravidity, parity, birthweight percentile at first delivery, and smoking showed no significant association between different IPI groups and SGA recurrence compared to the control group.

Conclusion:

Conclusion: Approximately one-fifth of women with a previous SGA child will experience a recurrence. No significant association was found between IPI and SGA recurrence. Further studies are needed to identify factors that can prevent SGA recurrence.